The School of Nursing currently has 1486 alumni. Of these, 232 completed the RN-to-BSN track and 1254 completed the generic track. Of the 1254 generic track graduates, 1252 have passed the NCLEX exam for RN licensure and one has received LPN licensure, resulting in an overall NCLEX pass rate of 99.841%.

Graduates of the Mississippi College School of Nursing hold a variety of leadership and management positions. Some of these include: Past Policy Fellow, National Council of State Boards of Nursing, Chicago, Ill; Past President of the National Council of State Boards of Nursing and Past Executive Director of the Mississippi Board of Nursing; current and past members of the Mississippi Board of Nursing; Assistant Administrators/Chief Nursing Officers of University Medical Center and River Oaks East, Women's Pavilion; Directors of Nursing at Mississippi Baptist Medical Center, University Hospital at Durant, Methodist Hospital at Lexington; Past President of the Alabama League for Nursing; Dean of Nursing and Allied Health at Hinds Community College; Deans of Schools of Nursing at Mississippi College and William Carey College; District 5 Coordinator of the Mississippi State Board of Health; and many faculty members in nursing education programs both in Mississippi and nationally. Alumni are now serving as officers with the Armed Forces in various branches throughout the world. Several graduates are currently serving on the mission field in countries such as Chile, China, Guyana, Tanzania, and Yemen.

Mississippi College nursing graduates are highly recruited. While most graduates remain in the Jackson metropolitan area, many were also initially employed by agencies in surrounding states including Alabama, California, Louisiana, Tennessee, and Texas. The School of Nursing participates in an annual Career Day in early February in which representatives from more than 20 agencies display and discuss benefits and employment with students.

In 1990, the School of Nursing began recognizing an outstanding alumnae each year. This recognition is based on contribution to the profession of nursing and acknowledges leadership and service across the nursing spectrum.

Honorees include: