Hanna Broome, Ph.D.
My research focus originated during my postdoctoral fellowship at the University of Mississippi Medical Center, when I studied an animal model of systemic lupus erythematosus (SLE), an autoimmune disease that primarily affects women. Autoimmune diseases in general are the result of a number of factors, including genetic and environmental. Environmental factors have been shown to cause modifications in the organization of DNA, otherwise known as epigenetic changes, which alters expression of specific genes. My research focus is on the various environmental conditions that can lead to significant changes in DNA methylation and activation/suppression of certain genes, specifically those involved in the activity of the B and T cells of the adaptive immune system, which are important in the pathogenesis of autoimmune diseases like SLE.