Mississippi College

George (Trey) Howell III, Ph.D

Research Focus:

The prevalence of obesity and type 2 diabetes is increasing at alarming rate and represents a growing burden on the health care system of the United States. Until recently, an environmental mediator of type 2 diabetes had not been postulated.  However, recent studies from retrospective analysis of epidemiological data have suggested that high serum concentrations of certain persistent organic pollutants, including the organochlorine compounds DDE and oxychlordane, are positively correlated with increased prevalence of insulin resistance and diabetes. Thus my current focus is to determine if exposure to the organochlorine compounds DDE and oxychlordane promotes the occurrence of insulin resistance and type 2 diabetes through altering adipocyte maturation and inducing insulin resistance in the adipose tissue and skeletal muscle as indicated by decreased insulin signaling and decreased glucose uptake.  In order to determine if exposure to DDE promotes the occurrence of type 2 diabetes in the whole animal, a high fat fed animal model of type 2 diabetes will be employed. Taken together, the current proposal seeks to empirically determine whether exposure to either DDE or oxychlordane, two prevalent bioaccumulative environmental contaminants, promotes the occurrence of type 2 diabetes.  This line of investigation is of particular importance given that the origins of insulin resistance remain an enigma.

About Me

Doctorate of Pharmacology and Toxicology, May 2007
Department of Pharmacology and Toxicology
University of Mississippi Medical Center (UMMC)
Jackson, MS  39216

Dissertation Title: Butorphanol-Induced c-Fos Production Within the Paraventricular Nucleus of the Hypothalamus and Activation of the Hypothalamic Pituitary Adrenal Axis: Role of the Kappa Opioid Receptor

Bachelor of Science (Cum Laude),
Microbiology, May 2000
Mississippi State University
Mississippi State, MS  39762

Class Schedule

Fall 2011

  • BIO 111 - General Biology 1
    Monday, Wednesday, and Friday, 8-8:50 AM, Hederman 105
  • BIO 6305 - Cell Physiology
    Monday, 6-8 PM, Hederman 306

Spring 2012

  • BIO 305-B - Cell Biology
    Tuesday and Thursday, 9:25-10:40 AM, Hederman 312
  • BIO 410/54 - Human Gross Anatomy
    Tuesday, Wednesday, and Thursday, TTh 8:00-9:15 AM, W 1:30-3:30 PM, Hederman 105
  • PAS 6220 - Pharmacology and Pharmacotherapeutics II
    Thursday, 11:15 AM -12:15 PM, MEC



BIO 6305 Documents

Other Documents